SELECTIVE CLEAVAGE OFN-t-BUTOXYCARBONYL PROTECTING GROUP
نویسندگان
چکیده
منابع مشابه
The protecting-group free selective 3'-functionalization of nucleosides.
The direct and chemoselective 3'-phosphoramidation, phosphorylation and acylation of nucleosides are described. Upon the discovery of a novel 3'-phosphorylamidation of therapeutic nucleoside analogues with DBU, we explored the mechanism of this rare selectivity through a combination of NMR spectroscopy and computational studies. The NMR and computational findings allowed us to develop a predict...
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[reaction: see text]. N-Benzhydryl aziridines-2-carboxylates can be readily obtained from the catalytic asymmetric aziridination reaction from N-benzhydrylimines and ethyl diazoacetate. Cleavage of the benzhydryl group by hydrogenolysis leads to ring opening when R = aryl. Surprisingly, ozone will selectively oxidize the benhydryl group in these aziridines even when R is an aryl group. This all...
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The proper introduction and removal of protecting groups is one of the most important and widely carried out synthetic transformations in preparative organic chemistry. In particular, in the highly selective construction of complex, polyfunctional molecules, e.g., oligonucleotides, oligosaccharides, peptides, and conjugates thereof, and in the synthesis of alkaloids, macrolides, polyether antib...
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Functional group incompatibility in the synthesis of complex organic molecules has been a problem since the infancy of organic chemistry. Emil Fischer made a valuable contribution to organic chemistry when he came up with the notion that an otherwise reactive functional group could be temporarily rendered inert by attaching a suitable protecting group that could then later be removed [1]. Today...
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Pyrophosphate linkages have a number of important roles in biology and are also formed chemically with great ease. They often are unwanted products, such as in the nonenzymatic oligomerization of mononucleotides. We have found that Zr(4+)- and Th(4+)-ions catalyze the symmetrical hydrolysis of pyrophosphate linkages. Oligonucleotide analogs linked by pyrophosphate bonds are substantially degrad...
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ژورنال
عنوان ژورنال: Chemistry Letters
سال: 1974
ISSN: 0366-7022,1348-0715
DOI: 10.1246/cl.1974.631